Fig. 7.

Calculated Po₂ distributions for tissue volume surrounding array of parallel capillaries. Relative to control (red line), prediabetes (blue line) results in a shift of the Po₂ distribution to the left (decreased mean Po₂) and broadening (increased heterogeneity) of the Po₂ distribution curve. In prediabetes, increasing the entrance O₂ saturation and RBC supply rate to control levels (case 1, dashed green line) does not fully restore the Po₂ distribution to control. A further increase in RBC supply rate to twice control levels (case 2, dashed orange line) is required to restore tissue oxygenation.