Table 1.
WT group baseline and resuscitation period characteristics
| WTNT | WTTH | |
|---|---|---|
| n | 13 | 10 |
| Baseline | ||
| Body weight, g | 31.6 ± 2.3 | 32.0 ± 2.2 |
| Heart rate, beats/min | 292 ± 50 | 285 ± 20 |
| LVPmax, mmHg | 99.0 ± 11.4 | 101 ± 11.6 |
| dP/dtmax, mmHg/ms | 7.3 ± 1.2 | 8.2 ± 1.1 |
| τ, ms | 9.0 ± 1.2 | 9.0 ± 1.2 |
| Stroke volume, μl | 12.0 ± 2.1 | 12.4 ± 1.4 |
| Cardiac output, ml/min | 3.2 ± 0.5 | 3.5 ± 0.30 |
| PetCO2, mmHg | 32.3 ± 4.88 | 31.7 ± 7.16 |
| CPR | ||
| CC rate, beats/min | 342 ± 59 | 301 ± 41 |
| DBP, mmHg | 15.6 ± 3.6 | 19.3 ± 4.4 |
| PetCO2, mmHg | 20.4 ± 3.2 | 14.8 ± 3.6* |
| ROSC, n (%) | 9 (90) | 8 (80) |
| Time to ROSC†, s | 178 ± 61 | 141 ± 51 |
Values are means ± SD; n, number of mice. WT, wild-type; NT, normothermia; TH, therapeutic hypothermia; LVPmax, maximum left ventricular pressure; dP/dtmax, maximum rate of change in left ventricular pressure; τ, diastolic relaxation time constant; PetCO2, partial pressure end-tidal CO2; CC rate, chest compression rate; DBP, diastolic blood pressure during cardiopulmonary resuscitation (CPR); ROSC, return of spontaneous circulation.
*
P < 0.05, statistically significant difference by Student's t-test.
†
Calculated for subset of animals achieving ROSC.