Fig. 7.

Effect of ISO and CCPA on the phosphorylation of HSP27 in the isolated mouse heart. Hearts were perfused in the absence or presence of ISO (1 min) at 10 or 100 nM. When CCPA was administered, this A₁R agonist was infused for 5 min alone or 4 min before and during the ISO administration. Control and CCPA-alone values are repeated from Fig. 2 for comparison. See legend of Fig. 5 for details. Values are means ± SE of 3–9 hearts. *Mean is significantly different from the agent-free value (P < 0.05). †Mean is significantly different from the CCPA-alone value (P < 0.05).