Fig. 10.

Correlation between the early increase in BCECs and late loss of postictal cerebral vascular endothelial function. Seizures were induced in saline control piglets (n = 7) and in piglets pretreated with CORM-A1 (2 mg/kg ip, 30 min before seizures, n = 5) or with the HO-1 inducer CoPP (20 mg/kg ip, 24 h before seizures, n = 2). A: seizure-induced BCECs were immunodetected as CD146⁺/GLUT1⁺ mononuclear cells in blood collected during baseline measurements and 4 h after seizure onset. B: endothelium-dependent cerebral vascular reactivity to bradykinin (10⁻⁶ M) tested in control intact piglets (no seizures) and 2 days after seizures. *P < 0.05 compared with intact control values; †P < 0.05 compared with seizure saline control values.