Fig. 4.

Effect of endothelium (Endo) removal on Phe-induced contraction in aortic rings of WT and cav-1^−/− mice on HS diet and nontreated or treated with Epl. Endothelium intact (open symbols) and denuded aortic rings (closed symbols) of WT (A), WT + Epl (B), cav-1^−/− (C), and cav-1^−/− + Epl (D) mice were stimulated with increasing concentrations of Phe, and the contractile response was measured and presented in grams. Data represent means ± SE (n = 9 to 19). *Measurements in endothelium-denuded vessels are significantly different (P < 0.05) from corresponding measurements in intact vessels.