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Sodium nitroprusside (SNP)-induced relaxation in aortic rings of WT and cav-1−/− mice on HS diet and nontreated or treated with Epl. Aortic rings of WT and WT + Epl (A) or cav-1−/− and cav-1−/− + Epl (B) were precontracted with Phe (10−5 M), increasing concentrations of SNP were added, and the percent relaxation of Phe contraction was measured. Data represent means ± SE (n = 12 to 17).
