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. 2010 Apr 2;298(6):H1850–H1856. doi: 10.1152/ajpheart.00114.2010

Fig. 4.

Fig. 4.

The phosphatidylinositol 3-OH-kinase inhibitor LY-294002 increased the permeability of endothelial monolayers exposed to CSS (P = 0.003; A) but had no effect on the permeability of unsheared (static) controls (P = 0.19; B). Similarly, the soluble guanylyl cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ) increased the permeability of endothelial monolayers exposed to CSS (P = 0.006; C) but had no effect on the permeability of unsheared (static) controls (P = 0.45; D). As in Fig 2, CSS decreased permeability relative to static controls (P = 0.009, one-tailed). n = 12–19. **P < 0.01.