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The cyclooxygenase inhibitor indomethacin did not alter the permeability of monolayers exposed to ASS (P = 0.60; A) or the corresponding unsheared (static) controls (P = 0.19; B). Similarly, it did not alter the permeability of monolayers exposed to CSS (P = 0.48; C) or the corresponding unsheared (static) controls (P = 0.46; D). As in Fig 2, ASS increased permeability and CSS decreased it, relative to static controls (P = 0.03 and 0.0001, one-tailed). n = 11–20.
