Fig. 2.
Fetal and adult CA tension and [Ca2+]i responses to phenylephrine (Phe) under control conditions and in the presence of α1A-AR inhibition by 5-methyl-6[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil (5-MU, 10−8 M). A and D: vascular tensions (g) for fetal CA (A) and adult CA (D) in response to Phe alone and in the presence of 10−8 M 5-MU (n = 4). B and E: fluorescence ratio (F340/380), i.e., [Ca2+]i for fetal CA (B) and adult CA (E) in response to Phe alone or after 5-MU. C and F: fetal (C) and adult (F) CA tension responses to Phe under control conditions and in the presence of α1A-AR inhibition by 2-(2,6-dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride (WB-4101). (n = 4 to 5 each.)