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Fetal and adult CA tension and [Ca2+]i responses to Phe under control conditions and in the presence of α1D-AR inhibition by 8-(2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl)-8-azaspiro(4,5)decane-7,9-dione (BMY-7378; BMY). A and C: vascular tension (g) for fetal (A) and adult (C) in response to Phe alone and in the presence of 10−7 M BMY-7378 (n = 4 each). B and D: fluorescence ratio (F340/380) for fetal (B) and adult (D) CA in response to Phe alone or after 10−7 M BMY-7378 (n = 4 each).
