Table II.
Results of cognitive testing comparing PD, MSA and DLB groups. Values shown are mean +/- standard deviation. Maximum score is shown in ( ) where applicable. Tests with significant group differences have p-value shown. (n.s. not significant). Post-hoc tests were performed after correction for multiple comparisons (*p<.05; **p<.01; ***p<.001). # The VOSP number location test scores were not significantly different between groups after correction for multiple comparisons.
| PD | MSA | DLB | Group effect | Posthoc tests | |
|---|---|---|---|---|---|
| MMSE (30) | 28.8 ± 1.4 | 27.3 ± 2.5 | 27.0 ± 1.7 | p =.027 | DLB<PD* |
| ModTrails: Time (120”) | 50.3” ± 19.7 | 85.5” ± 25.3 | 100.3” ± 35.2 | p =.001 | MSA>PD***, DLB>PD*** |
| ModTrails: # Correct (14) | 14.0 ± 0.0 | 12.1 ± 4.0 | 7.6 ± 5.7 | p =.002 | DLB<MSA*; DLB<PD*** |
| ModTrails: # Errors | 0.3 ± 0.5 | 1.3 ± 1.1 | 1.4 ± 1.2 | p =.023 | MSA>PD*; DLB>PD* |
| Design Fluency: # Correct | 10.3 ± 3.6 | 7.1 ± 2.0 | 5.1 ± 2.8 | p =.003 | MSA<PD*; DLB<PD*** |
| Design Fluency: # Errors | 2.6 ± 2.8 | 2.3 ± 1.9 | 1.4 ± 1.3 | n.s. | |
| Stroop Interference: # Correct | 44.5 ± 14.6 | 31.9 ± 11.1 | 20.5 ± 14.3 | p =.001 | DLB<MSA*; DLB<PD*** |
| Stroop Interference: # Errors | 1.1 ± 1.4 | 1.1 ± 2.2 | 2.3 ± 2.5 | n.s. | |
| Digits Backward (Span) | 4.7 ± 1.2 | 4.1 ± 1.5 | 3.9 ± 1.4 | n.s. | |
| CVLT-SF: Learning (36) | 24.9 ± 6.9 | 24.1 ± 3.8 | 17.3 ± 4.8 | p =.006 | DLB<MSA***; DLB<PD* |
| CVLT-SF: 30” Recall (9) | 6.0 ± 2.2 | 6.4 ± 2.0 | 4.3 ± 2.2 | n.s. | |
| CVLT-SF: 10’ Recall (9) | 5.9 ± 2.3 | 5.5 ± 2.2 | 3.4 ± 1.7 | p =.015 | DLB<MSA*; DLB<PD* |
| CVLT-SF: Recog. (9) | 8.3 ± 0.8 | 8.1 ± 1.0 | 7.6 ± 1.9 | n.s. | |
| CVLT-SF: Recog. False + | 0.6 ± 0.8 | 0.4 ± 0.8 | 2.6 ± 2.3 | p =.007 | MSA<DLB***; PD<DLB* |
| ModRey: Copy (17) | 15.6 ± 1.0 | 13.4 ± 2.1 | 13.9 ± 2.3 | p =.014 | MSA<PD***; DLB<PD* |
| ModRey: Recall (17) | 9.2 ± 4.4 | 8.7 ± 2.4 | 6.8 ± 3.6 | n.s. | |
| VOSP: Number Location | 9.0 ± 0.9 | 8.6 ± 2.8 | 7.4 ± 2.8 | p =.043# | |
| M's & N's (2) | 0.5 ± 0.9 | 1.3 ± 0.9 | 1.5 ± 0.9 | p =.020 | MSA>PD*; DLB>PD* |
| Sentence Repetition (3) | 2.5 ± 1.0 | 3.0 ± 0.8 | 2.7 ± 0.6 | n.s. | |
| D words: # Correct | 14.9 ± 6.7 | 10.0 ± 3.5 | 10.1 ± 5.5 | n.s. | |
| Animals: # Correct | 19.2 ± 5.8 | 12.9 ± 4.7 | 11.1 ± 5.4 | p =.003 | MSA<PD***; DLB<PD*** |
| 15-Item BNT: # Correct | 14.2 ± 1.2 | 13.5 ± 1.6 | 14.1 ± 1.1 | n.s. | |
| FAQ | 3.8 ± 4.1 | 7.0 ± 5.2 | 16.9 ± 7.9 | p =.001 | MSA<DLB***;PD<DLB*** |
| GDS | 11.9 ± 7.4 | 14.9 ± 5.7 | 11.3 ± 7.6 | n.s. |