Fig. 4.

Genes identified as being able to predict which subjects demonstrate high response to exercise training formed a gene network found to be related to development. A: predictor genes (gray symbols with blue labeling) are not regulated by exercise (Table 1). Additional genes within the network represent genes known to interact with the predictor genes. B: genes shown in red are those that are increased by exercise training in group 1 (while those shown in blue are decreased). This demonstrates that most of the predictor genes, and many of those with which they interact in this analysis, are not responsive to regular exercise. Several members of the network are, however, known to be regulated by exercise at the protein level.