Table 1.
Stepwise regression model for standardized residuals of maximal oxygen consumption training response in the HERITAGE Family Study
|
r2 |
|||||||
|---|---|---|---|---|---|---|---|
| Gene (SNP) | Identification Method | RNA-Level Correlation | RNA Stable to Exercise | Genomic Location | Partial | Model | P |
| SVIL (rs6481619) | QTL | Yes (+) | Yes | 10p11.2 | 0.0411 | 0.0411 | <.0001 |
| SLC22A3 (rs2457571) | RNA predictor | Yes (+) | Yes | 6q26-q27 | 0.0307 | 0.0718 | 0.0003 |
| NRP2 (rs3770991) | QTL | Yes (+) | Yes | 2q33.3 | 0.0224 | 0.0942 | 0.0017 |
| TTN (rs10497520) | QTL | No | Yes | 2q31 | 0.0204 | 0.1146 | 0.0025 |
| H19 (rs2251375) | RNA predictor | Yes (+) | No | 11p15.5 | 0.0268 | 0.1414 | 0.0004 |
| ID3 (rs11574) | RNA predictor | Yes (+) | Yes | 1p36.13-p36.12 | 0.02 | 0.1615 | 0.0021 |
| MIPEP (rs7324557) | QTL | Yes (−) | Yes | 13q12 | 0.0163 | 0.1778 | 0.0051 |
| CPVL (rs4257918) | RNA predictor | Yes (+) | Yes | 7p15-p14 | 0.0179 | 0.1957 | 0.0031 |
| DEPDC6 (rs7386139) | RNA predictor | Yes (+) | Yes | 8q24.12 | 0.0112 | 0.2069 | 0.0185 |
| BTAF1 (rs2792022) | RNA predictor | Yes (+) | Yes | 10q22-q23 | 0.0125 | 0.2194 | 0.0122 |
| DIS3L (rs1546570) | RNA predictor | Yes (+) | Yes | 15q22.31 | 0.0095 | 0.2289 | 0.0279 |
Residual maximal oxygen consumption response values were adjusted for age, sex, baseline body weight, and baseline maximal oxygen consumption (n = 473). RNA determinations were made using U133 Plus 2.0 Affymetrix chips, normalized using MAS5.0, and tested for differential expression using significance analysis of microarrays (SAM). In total, ∼1,000 probe sets were deemed differentially expressed (>1.5-fold change, <5% false discovery rate). Only 1 predictor/genetic association gene belonged to this group of regulated genes. SNP, single-nucleotide polymorphism; QTL, quantitative trait locus.