Fig. 13.

Cardiovascular phenotype of ASIC2 deletion in mice. Values were obtained from continuous recordings of MAP and HR, which increased in ASIC2 knockout (KO) mice. Motor activity was reduced (gray lines and columns) when compared with wild-type (WT; black lines, white columns). †Significant differences at specific time points throughout the diurnal cycle, as well as in the average 24-h measurements represented in the bar graphs for MAP, HR, and locomotor activity (P < 0.05 by 2-way ANOVA). [From Lu et al. (48).]