Fig. 2.

Gastric hemorrhaging and mild hypochlorhydria in KO mice. A: everted stomachs of KO mice subjected to overnight fasting reveal hemorrhaging of the glandular stomach with varying levels of severity, from focal bleeding (left), mild but more diffuse bleeding (center), to severe hemorrhaging (right). B: measurements of gastric pH after overnight fasting and stimulation with histamine revealed mild hypochlorhydria in KO (−/−) mice relative to WT (+/+) mice. KO mice were separated based on the presence of blood on the lumenal surface of the stomach (bleeding) or the absence of any detectable hemorrhaging (no bleeding). For mice with no signs of hemorrhage: n = 5 (WT) and 8 (KO) mice; for mice in which bleeding was detected: n = 4. *P < 0.05 compared with WT based on a Student's t-test.