Fig. 5.
Capsaicin-induced TRPV1 desensitization and reversal caused by ATP on kidney projecting sensory neurons. A: representative trace shows that repeated capsaicin applications induce TRPV1 desensitization. B: mean data of experiments illustrated in A. Data are expressed as means ± SE; n = 6 neurons from 4 rats. C: representative trace shows that ATP (100 μM) reversed capsaicin-induced TRPV1 desensitization. D: mean data of experiments illustrated in C. Data are expressed as means ± SE; n = 7 neurons from 6 rats. CAP1, CAP2, and CAP3 represent the sequence of capsaicin applications *P < 0.01 vs. first capsaicin application. #P < 0.01 vs. second capsaicin application.