Fig. 7.

ATP-induced TRPV1 resensitization is mediated by P2Y₂ receptors on kidney projecting sensory neurons. A: representative recordings showing that the P2Y₁ receptor agonist, 2-Me-S-ATP (100 μM) does not reverse capsaicin-induced TRPV1 desensitization. B: mean data of experiments illustrated in A. Data are expressed as means ± SE; n = 6 neurons from 4 rats. C: representative trace shows that UTP (50 μM) reverses capsaicin-induced TRPV1 desensitization. D: mean data of experiments illustrated in C. Data are expressed as means ± SE; n = 6 neurons from 6 rats. *P < 0.01 vs. first application of capsaicin. #P < 0.01 vs. second application of capsaicin.