Fig. 8.
ATP-induced TRPV1 resensitization is not blocked by P2Y1 receptor or non-P2Y2 receptor antagonist. A: representative recordings showing that the P2Y1 receptor antagonist, MRS 2179 (10 μM), does not block ATP-induced TRPV1 resensitization. B: mean data of experiments illustrated in A. Data are expressed as means ± SE; n = 6 neurons from 3 rats. C: representative trace shows that pyridoxal-phosphate-6-azophenyl-2′,4′-disulfonic acid (PPADS) (10 μM) does not block ATP-induced TRPV1 resensitization. D: mean data of experiments illustrated in C. Data are expressed as means ± SE; n = 4 neurons from 2 rats. *P < 0.01 vs. first application of capsaicin. #P < 0.01 vs. second application of capsaicin.
