Table 1.
Summary of comparison between thick scar of the female Duroc pig and human hypertrophic scar
| Shallow female Duroc wounds | Deep female Duroc wounds | Human wounds that develop hypertrophic scar | |
|---|---|---|---|
| Healed at 3 weeks | Yes | No | No |
| Shallow female Duroc scar | Deep female Duroc scar | Human hypertrophic scar | |
| Scar raised above surrounding skin | No | Up to 2 mm | Up to 1 cm |
| Color of scar is red | No | No | Yes |
| Scar is thicker than uninjured skin | No | Yes | Yes |
| Disorganized collagen | No | Yes | Yes |
| Whorls/nodules | No | Yes | Yes |
| Elevated mast cell counts | No | Yes | Yes |
| Myofibroblasts | Yes at 1, 2, and 3 weeks | Yes at 1, 2, and 3 weeks | Yes |
| Shallow female Duroc |
Deep female Duroc wounds |
Human hypertrophic scar | |||
|---|---|---|---|---|---|
| Early | Late | Early | Late | ||
| TGFβ1 | |||||
| Protein | ↑ | ↑ | |||
| mRNA | ↑ | ↑ | ↑ | ||
| IGF-1 | |||||
| Protein | ↑ | ↑ | ↑ | ↑ | |
| mRNA | ↑ | ↑ | ↑ | ↑ | |
| Decorin | |||||
| Protein | ↓ | ↓ | ↓ | ||
| Versican | |||||
| Protein | ↑ | ↑ | ↑ | ||
| NO | ↓ | ↓ | ↓ | ||
| Nerve fiber counts | ↑ | ↑ | |||
NO, nitric oxide.