TABLE 3.

Location and magnitude of the most significant correlations between disease category (CDR score 0, 0.5 and 1.0) and lower regional-to-whole brain CMRgl (N = 298)

Brain Region		Atlas Coordinates			Correlation Coefficient	Z-score	P-value
		X	Y	Z
Posterior Cingulate		−8	−51	32	−0.47	7.6	1.1×10−16
Precuneus	Left	−8	−53	24	−0.46	7.5	1.1×10−16
	Right	8	−51	25	−0.49	7.8	4.4×10−16
Parietal	Left	−53	−47	36	−0.42	6.5	2.5×10−14
	Right	50	−51	39	−0.47	7.6	4.4×10−16
Temporal	Left	−63	−34	−12	−0.41	7.1	4.8×10−14
	Right	67	−32	−12	−0.41	7.1	5.9×10−14
Frontal	Left	−26	27	33	−0.24	4.2	1.2×10−5
	Right	45	27	35	−0.26	4.6	1.9×10−6
Medial Temporal	Left	−59	−49	−8	−0.36	6.4	6.3×10−11
	Right	67	−32	−12	−0.41	7.1	5.9×10−14
Occipital	Left	−38	−73	41	−0.37	6.5	3.2×10−11
	Right	36	−62	33	−0.26	5.7	3.9×10−6

The reported significance levels are uncorrected for multiple comparisons (p < 0.001).

^†Atlas coordinates for the maximal CMRl reductions were obtained from Talairach and Tournoux (1988). X is the distance to the right (+) or left (−) of the midline, Y is the distance anterior (+) or posterior (−) to the anterior commissure, and Z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.