TABLE 5.

Location and magnitude of the most significant correlations between MMSE and lower regional-to-whole brain CMRgl in participants with probable Alzheimer’s disease (n = 74)

Brain Region		Atlas Coordinates			Correlation Coefficient	Z-score	P-value
		X	Y	Z
Temporal	Left	−63	−26	−16	0.39	3.6	1.9×10−4
Frontal	Left	−16	48	34	0.44	4.1	2.1×10−5
Fusiform	Left	−32	−24	−22	0.40	3.7	1.1×10−4
Striatum	Left	−18	16	−1	0.35	3.1	9.53×10−4

The reported significance levels are uncorrected for multiple comparisons (p < 0.001).

^†Atlas coordinates for the maximal CMRgl reductions were obtained from Talairach and Tournoux (1988). X is the distance to the right (+) or left (−) of the midline, Y is the distance anterior (+) or posterior (−) to the anterior commissure, and Z is the distance superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.