. Author manuscript; available in PMC: 2010 Jun 16.

Published in final edited form as: Ann Neurol. 2010 Mar;67(3):308–316. doi: 10.1002/ana.21953

TABLE 2.

Clinical Discrimination within APOE Genotype Groups

Biomarkers	CN vs aMCI		CN vs AD		aMCI vs AD
	AUROC	p	AUROC	p	AUROC	p
Aβ_1-42
ε4 noncarriers	0.67	<0.001	0.75	<0.001	0.57	0.28
ε4 carriers	0.58	0.20	0.64	0.03	0.56	0.19
t-Tau
ε4 noncarriers	0.63	0.003	0.78	<0.001	0.68	0.003
ε4 carriers	0.71	<0.001	0.75	<0.001	0.55	0.25
STAND score
ε4 noncarriers	0.68	<0.001	0.84	<0.001	0.70	0.001
ε4 carriers	0.84	<0.001	0.95	<0.001	0.69	<0.001

p Values are based on Wilcoxon rank sum test.

APOE = apolipoprotein E; CN = cognitively normal; aMCI = amnestic mild cognitive impairment; AD = Alzheimer disease; AUROC = area under the receiver operator curve; STAND = Structural Abnormality Index.