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. Author manuscript; available in PMC: 2011 May 27.
Published in final edited form as: Neuron. 2010 May 27;66(4):550–559. doi: 10.1016/j.neuron.2010.04.024

Figure 1.

Figure 1

Calcineurin substitutes for synaptic excitation in the mossy fiber LTP protocol. (A) EPSC amplitudes before and after hyperpolarizing steps (“hyp only”; t = 0; upper inset, left) and the standard induction protocol (“standard”; t = 15 min; upper inset, right). Right lower insets: example EPSCs before and after the two induction protocols. Scale bar, 10 ms. (B) EPSC amplitudes in the presence of active calcineurin (CaN*) before and after the hyperpolarizing step conditioning protocol (applied at t = 0; upper inset, left) and the standard induction protocol (applied at t = 25 min; upper inset, right). Right lower insets show example EPSCs before and after the two protocols. (C) Mean EPSC amplitudes before and after hyperpolarizing steps in neurons infused with CaN* (closed circles; n = 11) or in control conditions (open triangles; n = 8). Error bars represent s.e.m. (D) Mean EPSC amplitudes before and after 3-sec hyperpolarizing steps applied either with synaptic stimulation (open triangles; n = 6) or in the presence of CaN* (closed circles; n=6).