Fig. 1.

Partial bladder outlet obstruction (PBOO)-induced alteration in the voiding pattern and detrusor smooth muscle spontaneous contraction. A: analyzed data for urination frequency and void volume in sham and PBOO groups. B: representative organ bath recording (n = 5) of spontaneous contraction of detrusor muscle strips from sham and PBOO groups. Five small vertical boxes on the chart equal a 2-g force, and 5 small horizontal boxes equal 10 min. The amplitude of spontaneous contractions is ∼4-fold higher in the PBOO group than that for the sham control. C: representative recording of detrusor muscle strips force generation profile in response to 125 mM KCl. D: analyzed contractile data of detrusor muscle strips. Values are means ± SE. *Statistical significance, P < 0.05; n = 5.