FIG. 4.

Analysis of (a) BUN, (b) serum creatinine, (c) urinary clusterin, (d) urinary Kim-1, (e) urinary Lcn2, and (f) urinary Timp-1 in male Wistar rats treated with gentamicin for 1, 3, or 12/14 days. Data are presented as individual animals and color coded according to histopathology scores for PTD. Mean values of five individual animals per dose group are indicated by a black line. Statistical analysis was performed by ANOVA and Dunnett’s test. Statistical changes are indicated by *p < 0.05, **p < 0.01, and ***p < 0.001. Note: for urinary markers after 1 and 3 days of treatment, histopathology scores shown are from groups of rats treated in parallel, that is, animals no. 1–15 and 16–30, respectively.