TABLE 2.
Summary of Histopathological Observations in Kidneys of Male Wistar Rats Treated with BI-2, BI-3, Gentamicin, or IMM125 for 1, 3, and 14 Days
| Days of treatment | Histopathological change | BI-2 |
BI-3 |
Gentamicin |
IMM125 |
||||||||
| 0 mg/kg | 2.5 mg/kg | 15 mg/kg | 0 mg/kg | 100 mg/kg | 1000 mg/kg | 0 mg/kg | 25 mg/kg | 75 mg/kg | 0 mg/kg | 30 mg/kg | 100 mg/kg | ||
| 1 | PTD | − | − | +(1/5) | − | +(1/5) | − | − | − | − | − | +(1/5) | +(1/5) |
| Infiltrate: mononuclear cell | − | − | − | − | − | − | − | +(1/5) | +(2/5) | − | − | − | |
| Hyaline droplet: renal tubule | − | − | − | − | − | − | − | − | − | +(2/5) ++(1/5) | +(2/5) | +(1/5) ++(2/5) | |
| 3 | PTD | − | − | − | +(2/5) | +(2/5) +(1/5) | +(1/5) | − | − | − | − | +(1/5) | − |
| Infiltrate: mononuclear cell | − | − | − | − | +(1/5) | − | − | − | − | − | +(4/5) | +(1/5) | |
| Hyaline droplet: renal tubule | − | − | − | − | − | − | − | − | − | +(3/5) ++(/5) | +(2/5) | +(1/5) | |
| 14 | PTD | − | − | − | − | − | +++(2/5) ++++(1/5) | − | +(2/5) | ++(3/5) +++(2/5) | − | +(1/5) | +(1/5) ++(2/5) +++(2/5) |
| Infiltrate: mononuclear cell | − | − | − | − | − | − | − | +(3/5) | +(4/5) ++(1/5) | − | +(4/5) ++(1/5) | +(3/5) ++(1/5) +++(1/5) | |
| Hyaline droplet: renal tubule | − | − | +++(5/5) | − | − | − | − | − | − | +(4/5) | +(2/5) ++(1/5) +++(1/5) | +(5/5) | |
Note. −, lesion not observed; +, minimal; ++, mild; +++, moderate; ++++, high severity of lesion. The summary term PTD includes (a) basophilic tubule: proximal (BI-3 and IMM125), (b) degeneration/regeneration: renal tubule (gentamicin), and (c) necrosis: proximal tubule (BI-3 and gentamicin).