Table 2.

Alteplase dosing regimens and concomitant antithrombotic agents for the five patients.

Case	Initial dose (mg/kg)	Type of infusion	Alteplase protocol	Total infusion time
A	0.5 (over 6h)	Intermittent	0.5 mg/kg/hr (6 hrs)	19 hrs
B	None	Intermittent	0.5 mg/kg/hr (6 hrs)	2 hrs
C	0.3 (over 6h)	Continuous	0.1 mg/kg/hr, decreased to 0.05 mg/kg/hr, then increased to 0.1 mg/kg/hr	96 hrs
D	0.5 (over 1h)	Continuous	0.2 mg/kg/hr, increased to 0.5 mg/kg/hr, then decreased to 0.2 mg/kg/hr, then increased to 0.5 mg/kg/hr	72 hrs
E	0.6 (over 1h)	Continuous	0.2 mg/kg/hr×4 hr, increased to 0.35 mg/kg/hr, then to 0.5 mg/kg/hr	48 hrs