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Combination of food components and TRAIL. Flavonoids (luteolin, apigenin, baicalein, kaempferol, and isoliquiritigenin), carotenoids (halocynthiaxanthin and peridinin), isothiocyanate (sulforaphane), a metabolite of fatty acids, 15-deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), and a food additive (NDGA) up-regulate DR5 expression. Combining these food components with TRAIL drastically induces apoptosis in malignant tumor cells
