Table 6.
Bivariate genetic analyses (n = 258)
| RhoG | SE | p-Value | RhoE | SE | p-Value | |
|---|---|---|---|---|---|---|
| Phenotype: item-derived factors/YBOCS severity | ||||||
| Factor 1 (Taboo) factor scale score | 0.41 | 0.24 | n.s. | 0.36 | 0.15 | 0.03 |
| Factor 2 (Contamination/cleaning) factor scale score | 0.48 | 0.19 | 0.04 | 0.41 | 0.14 | 0.01 |
| Factor 3 (Doubts) factor scale score | 0.39 | 0.19 | n.s. | 0.44 | 0.14 | 0.009 |
| Factor 4 (Superstitions) factor scale score | 0.15 | 0.41 | n.s. | 0.63 | 0.11 | 3.4 × e−6 |
| Factor 5 (hoarding/symmetry) factor scale score | 0.78 | 0.10 | 0.0005 | 0.43 | 0.13 | 0.02 |
| YBOCS total sum score (one factor-model) | 0.72 | 0.13 | 0.002 | 0.57 | 0.12 | 0.001 |
| Phenotype: item-derived factors | ||||||
| Factor 1 (taboo)/Factor 2 (contamination) | 0.26 | 0.34 | n.s. | 0.28 | 0.14 | 0.05 |
| Factor 1 (taboo)/Factor 3 (doubts) | 0.80 | 0.22 | 0.01 | 0.24 | 0.15 | n.s. |
| Factor 1 (taboo)/Factor 5 (hoarding/symmetry) | 0.39 | 0.32 | n.s. | 0.52 | 0.11 | 0.003 |
| Factor 2 (taboo)/Factor 3 (doubts) | 0.50 | 0.22 | n.s. | 0.41 | 0.13 | 0.02 |
| Factor 2 (taboo)/Factor 5 (hoarding/symmetry) | 0.77 | 0.17 | 0.02 | 0.38 | 0.13 | 0.05 |
| Factor 3 (doubts)/Factor 5 (hoarding/symmetry) | 0.48 | 0.24 | n.s. | 0.66 | 0.10 | 0.001 |
RhoG shared genetic variance, RhoE shared environmental variance, SE standard error, ns not significant (p > 0.05)