Table 3.

Amsterdam I and II Criteria and Bethesda Guidelines

^*Syndrome-associated tumors include colorectal, endometrial, stomach, ovarian, pancreas, ureter or renal pelvis, biliary tract, and brain (usually glioblastoma as seen in Turcot syndrome) tumors, sebaceous gland adenomas and keratoacanthomas in Muir-Torre syndrome, and carcinoma of the small bowel; ^†MSI-H, microsatellite instability-high in tumors refers to changes in two or more of the five National Cancer Institute-recommended panels of microsatellite markers; ^‡Presence of tumor infiltrating lymphocytes, Crohn disease-like lymphocyte reaction, mucinous/signet-ring differentiation, or medullary growth pattern.