Table 5.
Microneutralization (MN) antibody titres in mouse sera against homologous and heterologous viruses
| Immunized with: | Immunization dose | MN titres against homologous virus* | MN titres against WSN | MN titres against H5N1 |
|---|---|---|---|---|
| PBS | <10 | <10 | <10 | |
| 6WF10att : 2H1N1 | 106† | 160 | 160 | <10 |
| 6WF10att : 2H1N1 | 105† | 80 | 80 | <10 |
| 6WF10att : 2ΔH5N1 | 106‡ | <10 | <10 | <10 |
| 6WF10att : 2ΔH5N1+booster | 106‡ | <10 | <10 | <10 |
| 6WF10att : 2H7N2 | 106‡ | 40 | <10 | <10 |
| 6WF10att : 2H7N2+booster | 106‡ | 160 | <10 | <10 |
*Sera were collected at 21 days post-immunization. The data represent pooled sera from four mice per group. MN assays were performed using homologous viruses: A/WSN/33 (H1N1), A/Vietnam/1203/04 (ΔH5N1) and A/Chicken/Delaware/VIVA/04 (H7N2).
†Titre in p.f.u.
‡Titre in TCID50.