Skip to main content
. 2010 May 18;53(12):4793–4797. doi: 10.1021/jm1000248

Table 2. In Vitro ADME Data for 1a.

    plasma protein
binding (% bound)
   microsome stabilityd
(% remaining)
solubility
(μg/mL)
pH 5.0/6.2/7.4		 permeabilitya,bPe (× 10−6 cm/s)
pH 5.0/6.2/7.4		 human
10 μM/1 μM		 mouse
10 μM/1 μM		 plasma stabilityc
(% remaining)
human/mouse		 human
10 μM/1 μM		 mouse
10 μM/1 μM
42/0.5/0.7 299/710/441 99.8/99.9 99.9/99.8 100/100 55/26 19/0.5
a

Compound at 50 μM.

b

PAMPA Pe: low 5 × 10−6, moderate 250 × 10−6, high 1000 × 10−6.

c

Plasma/PBS; compound at 40 μM, 3 h.

d

% remaining at 1 h.