Table 1.
Results of 11 single nucleotide polymorphisms selected for the risk model in the combined analysis of QTSCD and QTGEN
| Locus | Chromosome | Variant | Coded allele | Beta | Standard error | P value |
|---|---|---|---|---|---|---|
| RNF207 | 1 | rs846111 | C | 1.70 | 0.21 | 3.69 × 10-16 |
| NOS1AP | 1 | rs12143842 | T | 3.27 | 0.17 | 1.88 × 10-78 |
| ATP1B1 | 1 | rs10919071 | A | 1.78 | 0.22 | 1.20 × 10-15 |
| SCN5A | 3 | rs12053903 | C | -1.23 | 0.12 | 1.0 × 10-14 |
| PLN; C6orf204 | 6 | rs11970286 | T | 1.53 | 0.15 | 2.35 × 10-24 |
| KCNH2 | 7 | rs4725982 | T | 1.44 | 0.16 | 5.0 × 10-16 |
| KCNQ1 | 11 | rs12296050 | T | 1.62 | 0.19 | 2.80 × 10-17 |
| LITAF | 16 | rs8049607 | T | 1.34 | 0.17 | 5.78 × 10-15 |
| NDRG4; CNOT1 | 16 | rs37062 | G | -1.68 | 0.16 | 3.0 × 10-25 |
| LIG3 | 17 | rs2074518 | T | -1.05 | 0.12 | 6.0 × 10-12 |
| KCNJ2 | 17 | rs17779747 | T | -1.10 | 0.16 | 6.02 × 10-12 |
The KCNE1 non-synonymous D85N variant rs1805128 (see also Figure 2) was not included in our risk score. It was genome-wide significant in the QTGEN study, but could not be confirmed in the QTSCD study and the combined analysis due to limited genotyping coverage in QTSCD.