Table 1.
effect of -35 on mean viral load
| (a) Categorical analysis using B*27, B*57 and B*35Px as covariates | |||||
|---|---|---|---|---|---|
| Genotype | VL <2,000 % (n) | VL >10,0000 % (n) | Comparison | OR (95% CI) | P value |
| CC | 62.3 (104) | 37.7 (63) | CC vs. TT | 0.23 (0.14–0.38) | 1 × 10−8 |
| CT | 33.2 (120) | 66.9 (242) | CT vs. TT | 0.55 (0.36–0.84) | 0.006 |
| TT | 15.1 (45) | 85.0 (254) | CX vs. TT | 0.42 (0.29–0.62) | 1 × 10−5 |
| CXa | 42.3 (224) | 57.7 (305) | CC vs. CT | 0.4 (0.26–0.6) | 1 × 10−5 |
| (b) Continuous variable analysis using B*27, B*57 and B*35Px as covariates | ||||||
|---|---|---|---|---|---|---|
| Genotype | N | Mean logVL | SE | Difference between genotypes | 95% CI | P value |
| CC | 188 | 2.99 | 0.12 | CT–CC (0.44) | 0.24–0.64 | <0.0001 |
| CT | 409 | 3.43 | 0.11 | TT–CC (0.71) | 0.49–0.93 | <0.0001 |
| TT | 326 | 3.70 | 0.13 | TT–CT (0.27) | 0.10–0.44 | 0.002 |
n = 923; SE, standard error; CI, confidence interval.
n = 828; OR, odds ratio; CI, confidence interval.
a
CX = CC/CT genotypes.