Table 1.
Patients' characteristics, white blood cell count, C-reactive protein and interleukin-6 blood level and mortality
| Total N = 259 |
Sepsis N = 127 |
Severe sepsis N = 75 |
Septic shock N = 57 |
P value | |
|---|---|---|---|---|---|
| Age yrs, mean (SD) | 58.1 (18.6) |
54.7 (18.6) |
61.0 (17.3) |
61.7 (19.2) |
<0.05a,b |
| Male, n (%) | 180 (69.5) |
88 (69.3) |
55 (73.3) |
37 (64.9) |
ns |
| WBC (*103/mm3), mean (SD) | 14.0 (9.5) |
14.1 (8.1) |
15.2 (10.9) |
12.8 (11.0) |
ns |
| CRP (mg/dL), mean (SD) | 11.8 (9.1) |
10.0 (8.5) |
11.4 (9.3) |
15.6 (9.5) |
<0.001b |
| IL-6 (pg/mL), mean (SD) | 33,543 (136,974) |
8,398 (47,705) |
8,176 (37,975) |
118,435 (264,819) |
<0.001b,c |
| Gram positive bacteremia, n (%) | 168 (64.9) |
92 (72.4) |
51 (68.0) |
25 (43.9) |
<0.0005d <0.01e |
| Gram negative bacteremia, n (%) | 70 (27.0) |
28 (22.0) |
17 (22.7) |
25 (43.9) |
<0.005d <0.01e |
| Both of Gram positive and negative bacteremia*, n (%) | 15 (5.8) |
4 (3.1) |
4 (5.3) |
7 (12.3) |
<0.05d |
| Fungemia*, n (%) | 7 (2.7) |
3 (2.3) |
3 (4.0) |
1 (1.8) |
ns |
| Bacteremia caused by multiple organisms, n (%) | 16 (6.2) |
4 (3.1) |
4 (5.3) |
8 (14.0) |
<0.01d |
| Length of ICU stay (day), mean (SD) | 19.4 (21.7) |
20.6 (22.4) |
17.4 (17.7) |
19.5 (24.9) |
ns |
| Mortality (%) | 31.3 | 20.5 | 36.0 | 49.1 | <0.001d |
WBC, white blood cell count; CRP, C-reactive protein; IL-6, interleukin-6. *One case overlapping because Gram-positive bacteria and fungi were detected. aWith unpaired Student's T test, between sepsis group and severe sepsis group. bWith unpaired Student's T test, between sepsis group and septic shock group. c With unpaired Student's T test, between severe sepsis group and septic shock group. d With Chi square test, between sepsis group and septic shock group. e With Chi square test, between severe sepsis group and septic shock group.