Table 1.
Changes of concentrations ofCNS ischemia indicators during thefour experimental phases (T1 to T4).
| T1 (baseline) |
T2 (IAP = 20 mmHg) |
T3 (IAP = 45 mmHg) | T4 (desufflation) |
|||||
|---|---|---|---|---|---|---|---|---|
| IL-6 Blood | 635 (226) | 755 (254.8) | 584 (176) | 676.5 (207.5) | ||||
| p | 0.043 (T1 vs. T2) | 0.345 (T2 vs. T3) | 1.00 (T3 vs. T4) | |||||
| IL-6 CSF | 611.5 (328.8) | 917.5 (245.3) | 822 (291) | 825 (232) | ||||
| p | 0.028 (T1 vs. T2) | 0.043 (T2 vs. T3) | 0.715 (T3 vs. T4) | |||||
| TNFa Blood | 560 (798) | 1070.5 (446.5) | 710 (647) | 854 (597) | ||||
| p | 0.012 (T1 vs. T2) | 0.499 (T2 vs. T3) | 0.612 (T3 vs. T4) | |||||
| TNFa CSF | 118.5 (160.3) | 245 (331) | 195 (396.5) | 284.5 (497.5) | ||||
| p | 0.068 (T1 vs. T2) | 0.463 (T2 vs. T3) | 0.345 (T3 vs. T4) | |||||
| Lac Blood | 0.1 (1.85) | 1.15 (1.3) | 1.15 (1.375) | 1.15 (1) | ||||
| p | 0.752 (T1 vs. T2) | 0.496 (T2 vs. T3) | 0.6 (T3 vs. T4) | |||||
| Lac CSF | 1.4 (1.7) | 2.3 (1.3) | 1.6 (2.8) | 1.9 (1.6) | ||||
| p | 0.017 (T1 vs. T2) | 0.237 (T2 vs. T3) | 0.109 (T3 vs. T4) | |||||
CSF: cerebrospinal fluid; IL-6: interleukin 6, Lac: lactate, TNFa: tumor necrosis factor alpha. Data are displayed as median and interquartile range in parentheses. IL-6 and TNFa are expressed as pg/ml and lactate as mmol/L. Statistical significances (p < 0.05) are marked in bold. IAP, intra-abdominal pressure.