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. 2010 Mar 16;14(2):R35. doi: 10.1186/cc8913

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Copyright ©2010 Supinski et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Diaphragm force-frequency curves. Force generation was significantly lower at stimulation frequencies from 1 to 80 Hz for diaphragms from LPS treated animals (filled circles) than for control animals (open squares) (P < 0.001). Diaphragms from animals given both EPA (eicosapentanoic acid) and LPS generated forces significantly higher than diaphragms from animals given LPS alone for stimulation frequencies of 1, 20, 50 and 80 Hz (P < 0.01 for each comparison). Forces generated by the EPA+LPS group were similar to controls for 1, 10 and 20 Hz but were lower than controls for 50 and 80 Hz (P < 0.05). Force generation for muscles taken from animals given EPA alone was similar to levels for control animals. * indicates a significant statistical difference between endotoxin and all other groups.