Table 1.
Extravascular lung water and respiratory and hemodynamic parameters.
| Baseline | 0 | 60 minutes | 120 minutes | 180 minutes | 240 minutes | |
|---|---|---|---|---|---|---|
| EVLW (ml) | ||||||
| SE | 286 (72) a | 421 (93) | 395 (81) | 356 (57) | 346 (58) | 344 (63) |
| LE | 225 (30) a | 458 (42) | 415 (34) | 387 (27) | 354 (40) | 331 (45) |
| SE+PEEP | 309 (80) a | 446 (64) | 383 (60) | 371 (70) | 367 (75) | 363 (73) |
| LE+PEEP | 269 (37) a | 491 (56) b | 436 (28) b | 389 (54) | 366 (43) | 349 (46) |
| PaO2/FiO2 | ||||||
| SE | 346 (148) b | 167 (91) | 193 (95) | 204 (121) | 216 (134) | 221 (141) |
| LE | 416 (128) b | 100 (36) | 96 (49) | 118 (44) | 169 (62) | 183 (54) |
| SE+PEEP | 269 (156) | 420 (74) c | 432 (89) c | 424 (107) c | 403 (127) c | 425 (121) c |
| LE+PEEP | 437 (69) | 202 (93) d | 262 (144) d | 401 (141) d | 505 (29) d | 539 (27) d |
| Pplat (mmHg) | ||||||
| SE | 11.8 (2.7) a | 15.3 (1.7) | 15.4 (2.2) | 15.3 (1.9) | 15.1 (2.2) | 14.9 (2.0) |
| LE | 10.8 (2.3) a | 17.1 (1.5) | 16.2 (3.0) | 15.2 (1.9) | 15.2 (2.3) | 15.4 (2.4) |
| SE+PEEP | 14.8 (3.4) a | 23.4 (3.1) e | 23.2 (1.6) e | 23.2 (1.7) e | 23.2 (1.7) e | 23.1 (1.8) e |
| LE+PEEP | 14.4 (4.5) a | 27.4 (7.4) f | 26.6 (4.9) f | 26.9 (4.7) f | 25.8 (4.3) f | 25.8 (4.7) f |
| MAP(mmHg) | ||||||
| SE | 68.2 (9.5) | 68.2 (9.3) a | 76.9 (12.3) | 82.7 (10.5) | 84.3 (9.6) | 87.3 (10.8) |
| LE | 77.2 (10.7) | 77.0 (5.1) | 80.2 (6.8) | 77.4 (5.7) | 81.2 (10.7) | 82.4 (12.8) |
| SE+PEEP | 59.0 (8.3) | 61.7 (5.5) | 69.8 (8.2) | 75.0 (9.6) | 76.2 (12.7) | 77.4 (13.3) |
| LE+PEEP | 70.4 (13.8) g | 52.4 (10.5) | 63.2 (5.4) | 66.8 (4.8) | 64.4 (4.8) | 64.7 (5.0) |
| CO (L/min) | ||||||
| SE | 3.7 (0.9) | 3.9 (1.0) | 4.5 (1.2) | 4.7 (0.9) | 4.6 (0.9) | 4.5 (0.9) |
| LE | 3.9 (1.2) | 3.9 (0.9) | 4.6 (1.4) | 4.5 (1.2) | 4.1 (0.9) | 3.9 (0.9) |
| SE+PEEP | 3.9 (0.7) | 4.7 (0.8) | 4.4 (0.9) | 4.2 (0.8) | 4.3 (0.9) | 4.1 (1.0) |
| LE+PEEP | 3.8 (1.1) b | 3.0 (1.0) d | 3.9 (0.8) d | 3.7 (0.9) d | 3.4 (0.8) d | 3.2 (0.7) d |
Data are expressed as mean (SD).
a Statistically significant differences with subsequent time points (P < 0.01).
b Statistically significant differences with subsequent time points (P < 0.05).
c Statistically significant differences between SE and SE + PEEP groups (P < 0.05).
d Statistically significant differences between LE and LE + PEEP groups (P < 0.05).
e Statistically significant differences between SE and SE + PEEP groups (P < 0.01).
f Statistically significant differences between LE and LE + PEEP groups (P < 0.01).
g Statistically significant differences between baseline and time 0 (P < 0.05). CO, cardiac output; EVLW, extravascular lung water; LE, large edema; LE + PEEP, large edema + positive end-expiratory pressure; MAP, mean arterial pressure; Pplat, plateau pressure; SE, small edema; SE + PEEP, small edema + positive end-expiratory pressure.