Table 1.
Baseline characteristics of patients with and without sepsis
| Patients with sepsis | Patients without sepsis | |||
|---|---|---|---|---|
| Variable | DEX (n = 31) | LZ (n = 32) | DEX (n = 20) | LZ (n = 19) |
| Age | 60 (46 to 65) | 58 (44 to 66) | 61 (50 to 68) | 60 (52 to 67) |
| Males | 58% | 41% | 57% | 53% |
| APACHE II | 30 (26 to 34) | 29 (24 to 32) | 27 (20 to 31) | 25 (20 to 30) |
| SOFA score | 10 (9 to13) | 9 (8 to 12) | 9 (8 to 12) | 8 (7 to 9) |
| IQCODE at enrollment | 3 (3 to 3) | 3 (3 to 3) | 3 (3 to 3) | 3 (3 to 3) |
| Medical ICU | 77% | 81% | 62% | 47% |
| Surgical ICU | 23% | 19% | 38% | 53% |
| Pre-enrollment lorazepam (mg) | 1.5 (0 to 5) | 0 (0 to 4) | 0 (0 to 4) | 0 (0 to 2) |
| Enrollment RASS | -3 (-4 to -2) | -4 (-4 to -3) | -3 (-4 to 0) | -3 (-4 to -1) |
| SIRS criteria | ||||
| Temperature (Fahrenheit) | 37.5 (37 to 38.3) | 38 (37.2 to 38.6) | 36.7 (35.8 to 37.8) | 37.2 (36.2 to 38.3) |
| White blood count (103/μL) | 12.5 (6.6 to 21.7) | 12.5 (7.7 to 18.8) | 14.6 (8.9 to17.9) | 10 (7.5 to14) |
| Systolic BP (mm Hg) |
88 (78 to 100) | 83 (79 to 100) | 92 (90 to 100) | 90 (80 to110) |
| Heart rate (per minute) |
113 (100 to 134) | 119 (96 to 130) | 80 (65 to123) | 107 (99 to 126) |
| Respiratory rate | 26 (20 to 33) | 33 (27 to 39) | 20 (15 to24) | 24 (20 to28) |
| Organ dysfunction at enrollment | ||||
| PaO2/FiO2 ratio | 128 (105 to 209) | 126 (94 to 198) | 127 (72 to 211) | 145 (81 to 223) |
| Creatinine (mg/dL) | 1.7 (0.8 to 2.9) | 1.0 (0.8 to 1.8) | 1.2 (1.0 to 1.7) | 0.9 (0.8 to 1.4) |
| Vasopressors | 32% | 56% | 19% | 5% |
| Bilirubin (mg/dL) | 0.5 (0.4 to 0.8) | 0.9 (0.4 to 1.8) | 0.6 (0.5 to 1.6) | 0.6 (0.4 to 1.1) |
| Platelets (103/μL) | 176 (61 to 304) | 183 (107 to 266) | 186 (101 to242) | 145 (114 to 242) |
Median (interquartile range) unless otherwise noted.
APACHE II, Acute Physiology and Chronic Health Evaluation II; BP, Blood pressure; DEX, dexmedetomidine; FiO2, fraction of inspired oxygen; IQCODE, Informant Questionnaire on Cognitive Decline in the Elderly; LZ, lorazepam; PaO2, partial pressure of arterial oxygen; RASS, Richmond Agitation-Sedation Scale; SIRS, Systemic Inflammatory Response Syndrome; SOFA, Sequential Organ Failure Assessment.