Table 3.
Hemodynamic parameters in patients with and without sepsis
| Patients with sepsis | Patients without sepsis | |||||
|---|---|---|---|---|---|---|
| Hemodynamic variable* | DEX (n = 31) |
LZ (n = 31) |
P value | DEX (n = 20) |
LZ (n = 19) |
P value |
| Number of days on vasoactive drugs | 1 (1) | 2 (2) | 0.08 | 1.5 (2.2) | 0.3 (0.9) | 0.08 |
| Average daily number of vasoactive drugs | 1.1 (0.2) | 1.6 (0.5) | 0.004 | 1.6 (0.9) | 1 (0) | 0.2 |
| Ever vasoactive drugs increased | 26% | 47% | 0.08 | 33% | 16% | 0.2 |
| Sinus bradycardia (<60 beats/min) | 13% | 6% | 0.4 | 24% | 0% | 0.02 |
| Sinus tachycardia (>100 beats/min) | 81% | 84% | 0.7 | 52% | 53% | 1 |
Mean (standard deviation) unless otherwise noted.
DEX, dexmedetomidine; LZ, lorazepam.
*Measured during 120-hour study drug protocol, except for sinus bradycardia and sinus tachycardia, which are measured during entire study.