Table 4.
Differences between patients with optimal (>64 μg/ml) and inadequate (<64 μg/ml) peak amikacin concentrations
| Peak >64 (n = 52) |
Peak <64 (n = 22) |
|
|---|---|---|
| Male | 32 (62) | 18 (81) |
| Nosocomial infections | 37 (71) | 15 (68) |
| Medical admission | 37 (71) | 13 (59) |
| Positive blood cultures | 18 (35) | 11 (50) |
| Shock/vasopressors | 40 (76) | 16 (72) |
| Mechanical ventilation | 37 (71) | 19 (86) |
| Age (years) | 62 ± 14 | 64 ± 13 |
| APACHE II score | 20 (16-25) | 23 (16-28) |
| SOFA score | 8 (5-10) | 9 (5-11) |
| Highest lactate (mmol/L) | 3.1 (1.5-4.8) | 2.8 (1.3-5.2) |
| Creatinine (mg/ml) | 1.6 ± 1.1 | 1.7 ± 1.3 |
| Albumin (g/dl) | 2.4 ± 0.8 | 2.4 ± 0.8 |
| Fluid balance (ml/24 h) | 2,589 ± 2,153 | 2,793 ± 2,085 |
Data are expressed as median (IQR), mean (± SD), or counts (percentage). APACHE, Acute Physiology and Chronic Health Evaluation; SOFA, Sequential Organ Failure Assessment.