Table 5.
Continuous sedative and analgesic infusions
| Observational period (n = 106, days = 553) |
Intervention period (n = 109, days = 556) |
P Value | |
|---|---|---|---|
| Propofol days (% of total days) | 307 (56%) | 283 (51%) | .006* |
| Mean dose/day (mg) ± SD | 2,592 ± 1,623 | 2,074 ± 1,308 | < .001* |
| Range (mg) | 550 to 7,910 | 510 to 7,070 | |
| Midazolam days (% of total days) | 49 (9%) | 80 (14%) | .078 |
| Mean dose/day (mg) ± SD | 238 ± 152 | 157 ± 122 | .001* |
| Range (mg) | 3 to 485 | 0 to 425 | |
| Fentanyl days (% of total days) | 137 (25%) | 114 (21%) | .171 |
| Mean dose/day (mcg) ± SD | 2,303 ± 1,606 | 4,919 ± 3,588 | < .001* |
| Range (mcg) | 80 to 8,000 | 100 to 16,000 | |
| Remifentanil days (% of total days) | 297 (54%) | 420 (76%) | .281 |
| Mean dose/day (mcg) ± SD | 6,888 ± 5,373 | 8,233 ± 6,384 | .003* |
| Range (mcg) | 1,000 to 18,000 | 1,000 to 19,000 | |
| Morphine days (% of total days) | 41 (7%) | 7 (1%) | .009* |
| Mean dose/day (mg) ± SD | 16 ± 9 | 10 ± 0 | .077 |
| Range (mg) | 7 to 40 | 10 to 10 | |
| Oxycodone days (% of total days) | 67 (12%) | 74 (13%) | .199 |
| Mean dose/day (mg) ± SD | 25 ± 22 | 20 ± 14 | .079 |
| Range (mg) | 5 to 100 | 3 to 69 |
Number of days (t-test), medication dose (Mann-Whitney), and * P value ≤ .05 significant. Range was calculated within limits of adequate sedation.