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Test of intracellular leptin signaling mediated by mutant leptin receptors. A) Among all ObRs, only ObRb mediated STAT3 activation 15 min after leptin treatment. Housekeeping gene β-actin was probed as a loading control. B) Among ObR constructs, ObR1137 induced a 268-fold increase of STAT1 transcriptional activation, shown by luciferase reporter activity. This contrasts with less activation by ObR860, ObR889, ObR895, and ObRc, and a 2439-fold increase mediated by ObRb.
