Figure 4.

CD4⁻8⁻ T-cell-type cytokine enhancement of generation of IFN-γ by mixed CD4 and CD8 T cells in the absence of CD4⁻8⁻ T cells. Columns and bars depict mean ± sd enhancement of IFN-γ generation attained by adding 1 or 2 cytokines to CD4⁻8⁻ T-cell-free CD4 + CD8 T cells from 3 healthy donors before stimulation by anti-CD3 + anti-CD28 antibodies for 3 d. The 100% control value represents level of IFN-γ production by same number of CD4 + CD8 T cells mixed with 3% CD4⁻8⁻ T cells before stimulation. ⁺P < 0.05, *P < 0.025, and **P < 0.01; t test.