TABLE 1.
Distinctive profile of expression of surface immune proteins by CD4−8− T cells
| Category/protein | Expression by T cells (%)
|
||||
|---|---|---|---|---|---|
| Functions | CD4−8− | CD4+ | CD8+ | ||
| Immune cell interactions | |||||
| CD58 (LFA-3) | T-cell–APC, CTL-target interactions | 87 | 54 | 81 | |
| CD161 | Th17 differentiation, survival | 50 | 75 | 54 | |
| CD40 | B-cell differentiation, Ig class switch | 8 | 14 | 25 | |
| CD154 (CD40L) | Ligand for CD40 | 3 | 1 | 1 | |
| Immune cellular adhesion | |||||
| CD50 (ICAM-3) | Binds to LFA-1, T–B-cell interactions | 100 | 100 | 100 | |
| CD47 (IAP) | ECM-induced [Ca2+]i, migration | 99 | 100 | 100 | |
| CD54 | Binds to ICAM-1, T-cell-endothelial interactions | 75 | 30 | 80 | |
| CD38 | Cyclic ADP-ribose ectoenzyme, many functions | 25 | 46 | 20 | |
| Immune cellular proliferation | |||||
| CD5 (Leu 1) | T-cell proliferation, Th functions | 97 | 100 | 92 | |
| CD45RA (PTP) | Roles in differentiation, coactivation | 69 | 60 | 87 | |
| CD4RO (PTP) | Roles in differentiation, activation | 49 | 39 | 16 | |
| Antigen recognition | |||||
| TCRαβ | T-cell activation, signaling | 35 | 100 | 100 | |
| TCRγδ | T-cell activation, signaling | 65 | 0 | 0 | |
| Costimulation of T-cell responses to antigens | |||||
| CD2 | Adhesion and costimulatory protein | 100 | 100 | 100 | |
| CD28 | Broadly activates T cells with TCRs | 84 | 96 | 51 | |
| Receptors for chemokines, other mediators | |||||
| CCR4 | Chemokine GPCR | 31 | 39 | 32 | |
| CCR5 | Chemokine GPCR | 41 | 6 | 16 | |
| CCR7 | Chemokine GPCR | 27 | 79 | 35 | |
| IL-18Rα | IL-18R-binding unit | 60 | 36 | 35 | |
| IL-18Rβ | IL-18R expression, IL-18 high-affinity binding | 8 | 2 | 6 | |
| CD210 | IL-10 receptor | 22 | 6 | 27 | |
| CXCR3 | Chemokine GPCR | 56 | 46 | 55 | |
| CXCR4 | Chemokine GPCR | 27 | 67 | 40 | |
| CXCR5 | Chemokine GPCR | 8 | 15 | 5 | |
| Other | |||||
| CD59 | Complement membrane attack complex inhibitor | 87 | 96 | 71 | |
| CD26 | Multifunctional serine dipeptidyl peptidase-4 | 43 | 85 | 39 | |
Values are means of results of 2 to 4 determinations. ECM, extracellular matrix; GPCR, G-protein-coupled receptor; PTP, protein tyrosine phosphatase.