Examples of c-Fos-protein expression (small black cell nuclei) in the infralimbic (IL) and prelimbic (PrL) cortices of the medial prefrontal cortex (leftmost columns) and in the core (NACc) and shell (NACs) of the nucleus accumbens (rightmost columns) following bilateral saline or NMDA infusion into the VH. VH NMDA infusion leads to enhanced c-Fos expression in both the IL and PrL of the mPFC and in the NAC, especially the NACs, in unlesioned cases (top row). In cases with bilateral fornix lesions (bottom row), VH NMDA-induced c-Fos expression remains high in the IL and PrL, but is largely absent in the NAC. Examples were selected because c-Fos expression in each was near the mean for its group. ac, anterior commissure; d, dorsal; fmi, forceps minor of the corpus callosum; LV, lateral ventricle; m, medial; Tu, tubercle.