c-Fos protein expression in unlesioned (sham) cases (n=22) compared to those with bilateral lesions of the fornix (n=26). As described in Figure 3, bilateral NMDA infusion into the VH led to significantly elevated c-Fos expression in the infralimbic and prelimbic cortices of the mPFC (Left) and in the core and shell of the NAC (Right) in unlesioned cases compared to matched cases that received vehicle infusions in the VH. In cases with bilateral fornix lesions, VH NMDA infusion persisted in elevating c-Fos expression in both regions of the mPFC, but had minimal effects on expression in both regions of the NAC compared to cases with vehicle infusions. *p < 0.05, **p < 0.01, ***p < 0.005, ****p = 0.0002.