Fig. 3.

THP increases anxiety in a shock-paired plus maze paradigm, following THP withdrawal. When tested in the elevated plus maze without a preceding shock (left panel), an anxiolytic dose of THP (10 mg/kg, i.p.) increased time in the open arm and open arm entries in control mice, but not in mice undergoing THP Wd. (*P<0.05 vs Vehicle, n=8–10). However, when tested following a brief shock (right panel), THP decreased open arm time, following THP Wd, in contrast to its effect in control mice, where it increased this parameter. (*P<0.05 vs Vehicle, n=17–26). The total number of arm entries (lower panel) was not altered by any experimental treatment