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. Author manuscript; available in PMC: 2010 Jun 17.
Published in final edited form as: Nat Neurosci. 2002 Aug;5(8):721–722. doi: 10.1038/nn888

Fig. 1.

Fig. 1

Low concentrations of alcohol potentiate GABA responses at α4β2δ receptors. (a) The effects of alcohol on responses to GABA (EC20 = 0.03 μM α4β2δ, 1.7 μM α1β2γ2s, 5.6 μM α4β2γ2s) were measured by two-electrode voltage-clamp recording at −70 mV in oocytes expressing recombinant GABAA receptors. Inset, representative traces showing currents activated by GABA in the absence and presence of 1 mM alcohol. (b) Effects of 1 mM alcohol on GABA(EC20)-gated currents at various GABAA receptor subtypes (n = 8–20, *P < 0.05). Experiments were conducted according to Institutional Animal Care and Use Committee guidelines.