Table 4.
Known miRNA mapped at the breakpoint regions.
| Cytogenetic Band | miRNA | miRNA position | Hematologic Malignancies involvement |
|---|---|---|---|
| 1p34.2 | mir-30e | chr1:40,992,614-40,992,705 | no |
| mir-30c-1 | chr1:40,995,543-40,995,631 | no | |
| 1q32.1 | mir-135b | chr1:203,684,053-203,684,149 | no |
| mir-29c | chr1:206,041,820-206,041,907 | CLL36,37, ALL37 | |
| mir-29b-2 | chr1:206,042,411-206,042,491 | AML38, ALL38 | |
| mir-205 | chr1:207,672,101-207,672,210 | no | |
| 2q37.1 | mir-562 | chr2:232,745,607-232,745,701 | no |
| 3p21.31 | mir-1226 | chr3:47,866,049-47,866,123 | no |
| mir-425 | chr3:49,032,585-49,032,671 | no | |
| mir-191 | chr3:49,032,805-49,033,396 | AML39, ALL40 | |
| mir-566 | chr3:50,185,763-50,185,856 | no | |
| 4p16.3 | mir-943 | chr4:1,957,909-1,958,002 | no |
| mir-571 | chr4:333,946-334,041 | no | |
| 6p12.3 | mir-586 | chr6:45,273,389-45,273,485 | no |
| 7p14.3 | mir-550-2 | chr7:32,739,118-32,739,214 | no |
| mir-548n | chr7:34,946,897-34,946,971 | no | |
| 11p15.4 | mir-675 | chr11:1,974,565-1,974,637 | no |
| mir-483 | chr11:2,111,940-2,112,015 | no | |
| 11q12.1 | mir-130a | chr11:57,164,997-57,165,585 | no |
| 11q13.1 | mir-1237 | chr11:63,892,650-63,892,751 | no |
| mir-192 | chr11:64,414,935-64,415,544 | no | |
| mir-194-2 | chr11:64,415,153-64,415,737 | no | |
| mir-612 | chr11:64,968,505-64,968,604 | no | |
| 11q21 | mir-548l | chr11:93,839,309-93,839,394 | no |
| 12p13.32 | mir-200c | chr12:6,942,873-6,943,440 | no |
| mir-141 | chr12:6,943,271-6,943,865 | no | |
| 12q13.13 | mir-1293 | chr12:48,914,192-48,914,262 | no |
| 12q13.2 | mir-196a-2 | chr12:52,671,789-52,671,898 | no |
| mir-615 | chr12:52,714,001-52,714,096 | no | |
| mir-148b | chr12:53,017,267-53,017,365 | no | |
| mir-1228 | chr12:55,874,554-55,874,626 | no | |
| mir-616 | chr12:56,199,213-56,199,309 | no | |
| mir-26a-2 | chr12:56,504,409-56,504,992 | no | |
| 13q14.12 | mir-16-1 | chr13:49,521,110-49,521,198 | CLL41, MDS42 |
| mir-15a | chr13:49,521,006-49,521,588 | CLL43, MM44 | |
| 14q11.2 | mir-208a | chr14:22,927,645-22,927,715 | no |
| mir-208b | chr14:22,957,036-22,957,112 | no | |
| 14q32.31 | miRNA cluster 1 | chr14:99,645,745--101,096,512 | AML45, B-cell malignancies46 |
| 14q32.31 | miRNA cluster 2 | chr14:99,645,745-103,653,604 | AML45, B-cell malignancies46 |
| 15q24.1 | mir-630 | chr15:70,666,612-70,666,708 | no |
| mir-631 | chr15:73,433,005-73,433,079 | B cell lymphomas47 | |
| 15q24.3 | mir-184 | chr15:77,289,185-77,289,268 | no |
| 16p11.2 | mir-1826 | chr16:33,873,009-33,873,093 | no |
| 17p13.1 | mir-195 | chr17:6,861,408-6,861,994 | CLL37, ALL37 |
| mir-497 | chr17:6,861,954-6,862,065 | no | |
| mir-324 | chr17:7,067,340-7,067,422 | no | |
| 17p13.3 | mir-22 | chr17:1,563,947-1,564,031 | no |
| mir-132 | chr17:1,899,952-1,900,052 | T-cell leukemia48 | |
| mir-212 | chr17:1,900,315-1,900,424 | no | |
| 17q25.3 | mir-657 | chr17:76,713,671-76,713,768 | no |
| mir-338 | chr17:76,714,278-76,714,344 | no | |
| mir-1250 | chr17:76,721,591-76,721,703 | no | |
| 19q13.32 | mir-330 | chr19:50,834,092-50,834,185 | no |
| mir-642 | chr19:50,870,026-50,870,122 | no | |
| mir-769 | chr19:51,214,030-51,214,147 | no | |
| mir-220c | chr19:53,755,341-53,755,423 | no | |
| 20q13.33 | mir-1-1 | chr20:60,561,708-60,562,278 | no |
| mir-133a-2 | chr20:60,572,314-60,572,915 | no | |
| mir-124-3 | chr20:61,280,297-61,280,383 | no | |
| mir-941-1 | chr20:62,021,238-62,021,326 | no | |
| mir-941-2 | chr20:62,021,545-62,021,633 | no | |
| mir-941-3 | chr20:62,021,657-62,021,745 | no | |
| mir-1914 | chr20:62,043,262-62,043,341 | no | |
| mir-647 | chr20:62,044,428-62,044,523 | no | |
| 21q22.13 | mir-802 | chr21:36,014,883-36,014,976 | no |
For each cytogenetic band identified in this study are reported known miRNAs, the mapping position derived from the UCSC database querying, and their implication in hematological malignancies according to literature data.